Screening, Brief Intervention, and Referral to Treatment (SBIRT) is an evidence-based system-level integrated care approach to identify, reduce, and prevent patterns of substance use that put the health of people with HIV at risk. SBIRT has three basic steps: (1) screening for level of substance use (alcohol and drugs), (2) providing a brief intervention to increase awareness of substance use risk and motivation to change behaviors, and (3) referring clients for further evaluation and treatment as needed. In collaboration with HIV experts, SBIRT experts, and community members, E2i adapted SBIRT for the Ryan White HIV/AIDS Program (RWHAP) and produced a toolkit that provides the resources needed to implement SBIRT within RWHAP settings and other HIV care organizations.