The Center for Innovation and Engagement (CIE), a HRSA Special Projects of National Significance (SPNS)-funded project of NASTAD, identifies, catalogs, and disseminates evidence-informed interventions that link, re-engage, and retain people with HIV in care, and supports the real-world replication of these interventions to help end the HIV epidemic. These interventions have been proven effective in engaging people with HIV who are not receiving HIV care or who are at risk of falling out of care. (en Espanol: El Centro para la Innovación y el Involucramiento.) Image Disclaimer. The photographs on this webpage are stock photos posed by models.
These interventions have been proven effective in engaging people with HIV who are not receiving HIV care or who are at risk of falling out of care. Each summary outlines the intervention components, outcomes, cost information (where available), and known challenges and solutions. Supplementary resources, such as publications and job aids, are also included.
Access the Compendium of Evidence-Informed Interventions

TAVIE Red is a mobile application that utilizes gamification to increase health and psychological self-management and assists case managers with connecting with clients.

Tailored service delivery model including increasing access to supportive services and the provision of HIV care services in community settings.










On-site buprenorphine treatment guided by an experienced HIV physician trained in MI techniques

A client-centered, resiliency-based model to link newly diagnosed individuals to HIV care


An initiative designed to link people newly diagnosed with HIV to care and treatment within 72 hours


A client-focused, personalized, Incremental Risk Reduction approach to improve linkage and retention in care among people leaving correctional facilities

A data to care (D2C) program that aims to increase retention in care and viral suppression among people with HIV by using prescription refill information to decrease the length of time between refills and reduce antiretroviral therapy (ART) interruption.
Intervention Cost Calculator (CC) facilitatee cost comparisons and selection of interventions of interest based on available resources.
Implementation of new interventions requires careful planning and budgeting to ensure sustainability. A cost analysis helps determine the resources needed to implement an intervention, the costs associated with the use of those resources, and the cost per client receiving the intervention.
Informed by local data entered by the user, the Cost Calculator provides estimates of total annual costs involved in implementing an intervention and cost per client that can be shared with leadership and other decision makers to select the intervention that best meets their array of services, client volume, and budget.
Access the Intervention Cost Calculator
The Center for Innovation and Engagement (CIE) is a HRSA Special Projects of National Significance (SPNS)-funded project that identifies, catalogs, disseminates and supports the replication of evidence-informed approaches and interventions to engage people with HIV who are not receiving care, or who are at risk of not continuing to receive care. To support the real-world replication of the cataloged interventions, CIE provides steps for implementation and resources such as, but not limited to, replication tips, job aids, a cost calculator, and technical assistance.
Additionally, CIE is supporting three intervention pilots at Howard Brown Health to assess replication and adaptation for implementation.
CIE, led by NASTAD’s Health Equity Team, builds on NASTAD’s longstanding achievements to make measurable differences in achieving equity in healthcare. NASTAD is a leading non-partisan, non-profit association that represents public health officials who administer HIV and hepatitis programs in the U.S. NASTAD’s sole mission is to end the intersecting epidemics of HIV, viral hepatitis, and related conditions.
This brief video describes how CIE identified and selected the evidence-informed approaches.
How Does CIE Define Evidence-Informed Approaches and Interventions?
Evidence-informed approaches and interventions are tools, strategies, or models that have been proven as a means of providing statistically significant improvements in HIV care and treatment outcomes for people with HIV.
How Did CIE Identify the Evidence-Informed Approaches and Interventions on this Site?
In collaboration with Northwestern University’s Center for Prevention Implementation Methodology and evidence and dissemination subject matter experts (SMEs), CIE identified and cataloged evidence-informed approaches and interventions by:
- Conducting a systematic literature review for studies that demonstrate the effectiveness of an intervention, include a clearly defined approach, prioritize linkage, retention or re-engagement components, and include statistically significant outcomes.
- Conducting key informant interviews with Request for Information (RFI) respondents who submitted innovative interventions for consideration.
- Assessing registries, inventories, abstracts, and posters from HIV-related conferences to discover interventions.
- Developing and applying a rubric to measure the strength of evidence for each intervention.
- Developing and applying an impact scoring rubric to measure feasibility, acceptability, appropriateness, relevance, reach, sustainability, and transferability of each intervention.
- Selecting high priority interventions from those ranking in the top 50th percentile based on strength of evidence and strength of impact.
What is the Basis for the Strength of Evidence Rubric?
This rubric is based on CDC’s Prevention Research Synthesis (PRS) criteria for:
- Evidence-Based Interventions (EBIs) for Linkage to, Retention in and Re-engagement in HIV Care (LRC), and
- Evidence-Informed Interventions (EIs) for Linkage to, Retention in and Re-engagement in HIV Care (LRC).
How Were Steps 5 and 6 of the Identification Process Implemented?
CIE convened an Evidence and Dissemination Expert Panel (EDEP) consisting of HIV healthcare experts from across the U.S. CIE presented interventions ranking in the top 50 percentile of strength of evidence to EDEP members, who each utilized the CIE-developed impact scoring rubric to measure the feasibility, acceptability, appropriateness, relevance, reach, sustainability, and transferability of each intervention.
EDEP members selected high priority interventions that ranked in the 50th percentile based on both strength of evidence and strength of impact.
Overview Video
Meet the people and organizations that worked to identify and disseminate evidence-informed interventions to support linkage, re-engagement, and retention in HIV care.
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Contact Information
Project Contacts:
HRSA Contacts:
Funding:
Recipient Organization: NASTAD
Grant number: U90HA31882
Project Period: 2018-2021