Evidence-Informed Interventions (E2i)

Using Evidence-Informed Interventions to Improve Health Outcomes among People Living with HIV (E2i) is a project from HRSA's Special Programs of National Significance (SPNS) to identify and provide support for the implementation of evidence-informed interventions to reduce HIV-related health disparities and improve health outcomes, including increasing retention in care, improving treatment adherence, and improving viral suppression for people with HIV.

Implementation and Technical Assistance Center

Fenway Community Health Center, Inc., in collaboration with AIDS United, is the Evidence-Informed Interventions Coordinating Center for Technical Assistance (E2i CCTA) for this project, under a four-year HRSA/HAB cooperative agreement (August 2017 - July 2021).

Twenty six Ryan White HIV/AIDS Program-funded recipients/subrecipients have been subawarded to support the implementation of evidence-informed interventions. The 11 evidence-informed interventions are across four focus areas:

Improving HIV Health Outcomes for Transgender Women

  • Healthy Divas (Divas)
    • Rutgers New Jersey Medical School: Newark, New Jersey
    • California Prostitutes Education Project, Inc.: Oakland, California
    • Birmingham AIDS Outreach Inc: Birmingham, Alabama
  • Transgender Women Engagement and Entry To Care Project (TWEET)
    • Henry Ford Health System: Detroit, Michigan
    • CrescentCare: New Orleans, Louisiana
    • CENTRO ARARAT, INC.: Ponce, Puerto Rico

Improving HIV Health Outcomes for Black Men Who Have Sex with Men (MSM)

  • Project Connect and Retention through Enhanced Contacts (Connect)
    • AIDS Taskforce of Greater Cleveland: Cleveland, Ohio
  • Motivational Interviewing with Peer Outreach (MI Peers)
    • Houston County Board of Health/dba North Central Health District- HOPE Center: Macon, Georgia
    • Broward House, Inc.: Fort Lauderdale, Florida
    • University of Mississippi Medical Center: Jackson, Mississippi
  • Text Messaging Intervention to Improve Antiretroviral Adherence among HIV Positive Youth (TXTXT)
    • AIDS Partnership Michigan: Detroit, Michigan
    • Research Foundation SUNY HEAT Program: Brooklyn, New York

Integrating Behavioral Health with Primary Medical Care for People with HIV

  • Buprenorphine Treatment for Opioid Use Disorder in HIV Primary Care (BUP)
    • Greater Lawrence Family Health Center: Methuen, Massachusetts
    • Consejo de Salud de Puerto Rico Inc.: Ponce, Puerto Rico
  • Improving Mood-Promoting Access to Collaborative Treatment (IMPACT)
    • La Clinica del Pueblo, Inc: Washington, D.C.
    • Oklahoma State University Center Health Sciences: Tulsa, Oklahoma
    • Health Emergency Lifeline Programs: Detroit, Michigan
    • Our Lady of the Lake Hospital, Inc: Baton Rouge, Louisiana
  • Screening, Brief Intervention, and Referral to Treatment (SBIRT)
    • The Poverello Center Inc: Wilton Manors, Florida
    • North Jersey Community Research Initiative: Newark, New Jersey

Identifying and Addressing Trauma among People with HIV

  • Trauma-Informed Approach & Coordinated HIV Assistance and Navigation for Growth and Empowerment (TIA/CHANGE)
    • Alaska Native Tribal Health Consortium: Anchorage, Alaska
    • Chicago Women’s AIDS Project: Chicago, Illinois
  • Cognitive Processing Therapy (CPT)
    • Western North Carolina Community Health56: Asheville, North Carolina
    • Positive Impact Health Centers: Decatur, Georgia
  • Seeking Safety (Safety)
    • Multicultural AIDS Coalition: Boston, Massachusetts
    • The Regents of the Univ. of Calif., U.C. San Diego: La Jolla, California

Evaluation Center

The University of California San Francisco will serve as the Evidence-Informed Interventions Evaluation Center (E2i EC) for this project. The goal of this four-year HRSA/HAB cooperative agreement (August 2017 - July 2021)  is to evaluate the outcomes and impact of the evidence-informed interventions implemented through the initiative.

This project is supported by the Health Resources and Services Administration’s (HRSA) HIV/AIDS Bureau (HAB) of the U.S. Department of Health and Human Services (HHS) under grant number U69HA31067, with funds provided by the Special Projects of National Significance program

Contact Information

Project Contacts:

Alex Keuroghlian, MD, MPH
Project Director, Implementation & Technical Assistance Center
Fenway Health
Janet Myers, PhD, MPH
Director, Evaluation Center
University of California, San Francisco

HRSA Contacts:

PO Name
Nicole Chavis
PO Title
Public Health Analyst
PO Name
Demetrios Psihopaidas, PhD, MA
PO Title
Project Officer, Evaluation Center


Funding Mechanism: Cooperative Agreement

Recipient Organization: Fenway Community Health Center, Inc., in collaboration with AIDS United (Implementation/TA) and University of California San Francisco (ETAC)

Grant number: U69HA31067 (Implementation /TA), U90HA31099 (ETAC)

Project Period: 8/1/2017 - 7/31/2021