Innovative Intervention Strategies (2iS)

This is a HRSA Special Programs of National Significance (SPNS) project titled Using Innovative Intervention Strategies to Improve Health Outcomes among People with HIV (2iS). It includes funding for a Coordinating Center for Technical Assistance (Fenway), an Evaluation Center (UCSF), and twenty demonstration sites.


  • To apply the HRSA HAB implementation science framework to identify innovative intervention strategies.
  • Implement and evaluate the intervention strategies at 20 Ryan White HIV/AIDS Program-funded recipient organizations. 
  • Provide technical assistance to support implementation at the sites.
  • Develop accessible dissemination products to promote the replication and scale-up of successful intervention strategies in the RWHAP and other HIV service organizations nationally. 

Focus areas

The project's focus includes three priority populations and one area of service delivery:

  • People with substance use disorder (SUD)
  • Lesbian, gay, bisexual, transgender, and queer (LGBTQ+) youth
  • People who are or have been justice involved
  • Using telehealth services

Demonstration sites

  • AIDS Taskforce of Greater Cleveland: Cleveland, Ohio 
  • Birmingham AIDS Outreach, Inc.: Birmingham, Alabama 
  • City of Hartford Department of Health and Human Services: Hartford, Connecticut 
  • Cooper University Hospital EIP: Camden, New Jersey 
  • Denver Health and Hospital Authority: Denver, Colorado 
  • Desert AIDS Project: Palm Springs, California 
  • Georgia Harm Reduction Coalition: Atlanta, Georgia 
  • Health Emergency Assistance of Detroit: Detroit, Michigan 
  • HIV Alliance: Eugene, Oregon 
  • Men’s Health Foundation: Los Angeles, California 
  • The Miriam Hospital: Providence, Rhode Island 
  • Newark Beth Israel Medical Center: Newark, New Jersey 
  • Our Lady of the Lake Hospital: Baton Rouge, Louisiana 
  • Positive Impact Health Centers: Duluth, Georgia 
  • Research Foundation SUNY HEAT: Brooklyn, New York 
  • University of California San Diego Mother, Child, Adolescent HIV Program: San Diego, California 
  • University of Illinois at Chicago: Chicago, Illinois 
  • University of Nebraska Medical Center: Omaha, Nebraska 
  • Vivent Health: Milwaukee, Wisconsin 
  • Yale University: New Haven, Connecticut 

Contact Information

Project Contacts:

Alex Keuroghlian, MD, MPH
Project Director, Coordinating Center for Technical Assistance
Fenway Health
Janet Myers, PhD, MPH
Director, Evaluation Center
University of California, San Francisco

HRSA Contacts:

PO Name
Tracy L. McClair, MSPH
PO Title
Health Scientist, Implementation Science Team
PO Phone
PO Name
Son Phan, MPH, MD
PO Title
Health Scientist, Implementation Science Team
PO Phone
PO Name
Demetrios Psihopaidas, PhD, MA
PO Title
HRSA HAB Division of Policy and Data


Funding Mechanism: Cooperative Agreement

Recipient Organization: The Fenway Institute, UCSF

Grant number: U90HA42154 (HRSA-21-076), U90HA42153 (HRSA-21-068)

Project Period: 8/1/2021-7/31/2025